Title : Impact of myeloperoxidase-LDL interactions on enzyme activity and subsequent posttranslational oxidative modifications of apoB-100.

Pub. Date : 2014 Apr

PMID : 24534704






5 Functional Relationships(s)
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1 Using MS, we further analyzed in vitro modifications of apoB-100 by hypochlorous acid (HOCl) generated by the MPO-H2O2-chloride system or added as a reagent. Hypochlorous Acid myeloperoxidase Homo sapiens
2 Using MS, we further analyzed in vitro modifications of apoB-100 by hypochlorous acid (HOCl) generated by the MPO-H2O2-chloride system or added as a reagent. Hypochlorous Acid myeloperoxidase Homo sapiens
3 Furthermore, differences were observed between LDL oxidized by reagent HOCl or HOCl generated by the MPO-H2O2-chloride system. Hypochlorous Acid myeloperoxidase Homo sapiens
4 We show that several HOCl-mediated modifications of apoB-100 identified in vitro were also present on LDL isolated from patients who have increased levels of plasma MPO and MPO-modified LDL. Hypochlorous Acid myeloperoxidase Homo sapiens
5 We show that several HOCl-mediated modifications of apoB-100 identified in vitro were also present on LDL isolated from patients who have increased levels of plasma MPO and MPO-modified LDL. Hypochlorous Acid myeloperoxidase Homo sapiens