Pub. Date : 2014 Apr 15
PMID : 24534490
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study was designed to investigate the effect of the macrolide antibiotic azithromycin on IL-6 generation in murine macrophages treated with lipopolysaccharide (LPS) from Prevotella intermedia, a pathogen implicated in inflammatory periodontal disease, and its mechanisms of action. | Azithromycin | interleukin 6 | Mus musculus |
| 2 | Azithromycin significantly suppressed IL-6 production as well as its mRNA expression in P. intermedia LPS-activated RAW264.7 cells. | Azithromycin | interleukin 6 | Mus musculus |
| 3 | In conclusion, azithromycin significantly attenuated P. intermedia LPS-induced production of IL-6 in murine macrophages via inhibition of NF-kappaB, STAT1 and STAT3 activation, which is possibly related to the activation of SOCS1 signaling. | Azithromycin | interleukin 6 | Mus musculus |