Pub. Date : 2014 Mar
PMID : 24534483
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Wogonin inhibits H2O2-induced angiogenesis via suppressing PI3K/Akt/NF-kappaB signaling pathway. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Mechanistic studies showed that wogonin suppressed H2O2-activated PI3K/Akt pathway and reduced the expression of vascular endothelial growth factor (VEGF) up-regulated by H2O2 in both protein and mRNA levels. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Then we further investigated the effect of wogonin on over-activated PI3K/Akt pathway by insulin-like growth factor-1 (IGF-1) and H2O2. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | We found that wogonin suppressed phosphorylation of Akt, up-regulation of VEGF and angiogenesis in vitro which was further induced by IGF-1 and H2O2. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Taken together, these results suggested that wogonin was potential in inhibiting H2O2-induced angiogenesis in vitro and in vivo via suppressing PI3K/Akt pathway and NF-kappaB signaling. | Hydrogen Peroxide | AKT serine/threonine kinase 1 | Homo sapiens |