Title : [Effects of testosterone on insulin sensitivity in liver cells and related molecular mechanisms].

Pub. Date : 2013 Dec

PMID : 24534355






3 Functional Relationships(s)
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1 RESULTS: The 24-week treatment of testosterone decreased the phosphorylation of Akt and GSK3beta in C57BL/6 adipose and liver tissues (43.1% +- 3.2% vs 77.1% +- 6.7%, 14.7% +- 6.7% vs 82.3% +- 2.0% respectively, P < 0.05). Testosterone AKT serine/threonine kinase 1 Homo sapiens
2 Pretreatment with 10(-8)-10(-6) mol/L testosterone within 36 h obviously increased the phosphorylation of Akt and GSK3beta (P < 0.05). Testosterone AKT serine/threonine kinase 1 Homo sapiens
3 Pretreatment with 10(-7) mol/L testosterone for 36 h followed by insulin stimulation and restimulation after 6 h interval obviously decreased the phosphorylation of Akt and GSK3beta (P < 0.05). Testosterone AKT serine/threonine kinase 1 Homo sapiens