Pub. Date : 2014
PMID : 24528038
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ellagic acid exerts anti-proliferation effects via modulation of Tgf-beta/Smad3 signaling in MCF-7 breast cancer cells. | Ellagic Acid | SMAD family member 3 | Homo sapiens |
| 2 | In this study, our aim was to investigate whether ellagic acid inhibits the proliferation of MCF- 7 human breast cancer cells via regulation of the TGF-beta/Smad3 signaling pathway. | Ellagic Acid | SMAD family member 3 | Homo sapiens |
| 3 | Moreover, SIS3 reversed the effects of ellagic acid on the expression of downstream targets of the TGF-beta/Smad3 pathway. | Ellagic Acid | SMAD family member 3 | Homo sapiens |
| 4 | In conclusion, ellagic acid leads to decreased phosphorylation of RB proteins mainly through modulation of the TGF-beta/Smad3 pathway, and thereby inhibits the proliferation of MCF-7 breast cancer cells. | Ellagic Acid | SMAD family member 3 | Homo sapiens |