Title : Ellagic acid exerts anti-proliferation effects via modulation of Tgf-β/Smad3 signaling in MCF-7 breast cancer cells.

Pub. Date : 2014

PMID : 24528038






4 Functional Relationships(s)
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1 Ellagic acid exerts anti-proliferation effects via modulation of Tgf-beta/Smad3 signaling in MCF-7 breast cancer cells. Ellagic Acid SMAD family member 3 Homo sapiens
2 In this study, our aim was to investigate whether ellagic acid inhibits the proliferation of MCF- 7 human breast cancer cells via regulation of the TGF-beta/Smad3 signaling pathway. Ellagic Acid SMAD family member 3 Homo sapiens
3 Moreover, SIS3 reversed the effects of ellagic acid on the expression of downstream targets of the TGF-beta/Smad3 pathway. Ellagic Acid SMAD family member 3 Homo sapiens
4 In conclusion, ellagic acid leads to decreased phosphorylation of RB proteins mainly through modulation of the TGF-beta/Smad3 pathway, and thereby inhibits the proliferation of MCF-7 breast cancer cells. Ellagic Acid SMAD family member 3 Homo sapiens