Title : Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells.

Pub. Date : 2014 Apr

PMID : 24525405






2 Functional Relationships(s)
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1 Consequently, the integrated ER stress signals, such as eIF2alpha, ATF4, BiP, and CHOP are altered accordingly to induce ER-Ca2+ release, reactive oxygen species (ROS) overproduction, and cell death in HLECs treated with VPA. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens
2 Consequently, the integrated ER stress signals, such as eIF2alpha, ATF4, BiP, and CHOP are altered accordingly to induce ER-Ca2+ release, reactive oxygen species (ROS) overproduction, and cell death in HLECs treated with VPA. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens