Pub. Date : 2014 May
PMID : 24522204
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prohibitin 2 represents a novel nuclear AKT substrate during all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In the human acute promyelocytic leukemia cell line NB4, nuclear AKT activity increases during all-trans retinoic acid (ATRA)-mediated differentiation. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In the human acute promyelocytic leukemia cell line NB4, nuclear AKT activity increases during all-trans retinoic acid (ATRA)-mediated differentiation. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | As nuclear AKT activity is associated with differentiation, we sought to identify the nuclear substrates of AKT that were phosphorylated after ATRA treatment. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | As nuclear AKT activity is associated with differentiation, we sought to identify the nuclear substrates of AKT that were phosphorylated after ATRA treatment. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | A proteomics-based search for nuclear substrates of AKT in ATRA-treated NB4 cells was undertaken by using 2D-electrophoresis/mass spectrometry (MS) in combination with an anti-AKT phospho-substrate antibody. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | A proteomics-based search for nuclear substrates of AKT in ATRA-treated NB4 cells was undertaken by using 2D-electrophoresis/mass spectrometry (MS) in combination with an anti-AKT phospho-substrate antibody. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 8 | Activation of nuclear AKT during ATRA-mediated differentiation results in the phosphorylation of several proteins, including PHB2, which may serve to coordinate nuclear-mitochondrial events during differentiation. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |