Title : Does increase in DNA repair allow "tolerance-to-insult" in chemical carcinogenesis? Skin tumor experiments with MGMT-overexpressing mice.

Pub. Date : 2014 Mar

PMID : 24519900






1 Functional Relationships(s)
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1 As MGMT efficiently protects cells from mutations by repairing O(6) -methylguanine, a miscoding lesion induced by MNU, the question whether MGMT is able to nullify carcinogenic lesions to an extent where they would be considered nonhazardous has been addressed. O-(6)-methylguanine O-6-methylguanine-DNA methyltransferase Mus musculus