Title : Serotonin receptor 6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos.

Pub. Date : 2014 Mar 21

PMID : 24497636






2 Functional Relationships(s)
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1 Moreover, dysfunctional MAO-A expression led to elevated levels of embryonic serotonin (5-hydroxytryptamine (5-HT)), and we found that knockdown of serotonin receptor-6 (5-Htr6) expression or pharmacologic inhibition of 5-Htr6 activity rescued the MAO-A knockdown phenotype and restored apoptotic activity in the developing brain. Serotonin monoamine oxidase A Mus musculus
2 Moreover, dysfunctional MAO-A expression led to elevated levels of embryonic serotonin (5-hydroxytryptamine (5-HT)), and we found that knockdown of serotonin receptor-6 (5-Htr6) expression or pharmacologic inhibition of 5-Htr6 activity rescued the MAO-A knockdown phenotype and restored apoptotic activity in the developing brain. Serotonin monoamine oxidase A Mus musculus