Title : Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4.

Pub. Date : 2014

PMID : 24492672






2 Functional Relationships(s)
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1 Intravenous administration of Ad-E4-122aT-hCYP3A4 at a dose of 2 x 10(11) virus particles/mouse produced a mouse exhibiting human CYP3A4 activity at a level similar to that in the human liver, as shown in the dexamethasone metabolic experiment using liver microsomes. Dexamethasone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Intravenous administration of Ad-E4-122aT-hCYP3A4 at a dose of 2 x 10(11) virus particles/mouse produced a mouse exhibiting human CYP3A4 activity at a level similar to that in the human liver, as shown in the dexamethasone metabolic experiment using liver microsomes. Dexamethasone cytochrome P450 family 3 subfamily A member 4 Homo sapiens