Pub. Date : 2014 Apr
PMID : 24492650
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This series of events is crucial to elicit the death pathway triggered by doxorubicin and is necessary to promote HuR function in post-transcriptional regulation of gene expression, because genetic ablation of PKCdelta caused the inability of HuR to bind its target mRNAs, topoisomerase IIalpha (TOP2A) included. | Doxorubicin | DNA topoisomerase II alpha | Homo sapiens |
| 2 | In in vitro select doxorubicin-resistant human breast cancer cell lines upregulating the multidrug resistance marker ABCG2, PKCdelta, and HuR proteins were coordinately downregulated together with the doxorubicin target TOP2A protein whose mRNA was HuR-regulated. | Doxorubicin | DNA topoisomerase II alpha | Homo sapiens |
| 3 | In in vitro select doxorubicin-resistant human breast cancer cell lines upregulating the multidrug resistance marker ABCG2, PKCdelta, and HuR proteins were coordinately downregulated together with the doxorubicin target TOP2A protein whose mRNA was HuR-regulated. | Doxorubicin | DNA topoisomerase II alpha | Homo sapiens |
| 4 | Therefore, we show here that PKCdelta, HuR, and TOP2A constitute a network mediating doxorubicin efficacy in breast cancer cells. | Doxorubicin | DNA topoisomerase II alpha | Homo sapiens |