Title : Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.

Pub. Date : 2014 Mar 14

PMID : 24492615






1 Functional Relationships(s)
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1 Finally, reactive oxygen species production and evidence of oxidative stress were significantly enhanced in GLUT1-OE MPhis; antioxidant treatment blunted the expression of inflammatory mediators such as PAI-1 (plasminogen activator inhibitor 1), suggesting that glucose-mediated oxidative stress was driving the proinflammatory response. Reactive Oxygen Species solute carrier family 2 member 1 Homo sapiens