Title : Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats.

Pub. Date : 2014 Apr

PMID : 24491314






3 Functional Relationships(s)
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1 Quercetin, a natural flavonoid, has been reported to ameliorate high fructose-induced rat insulin resistance and hyperlipidemia. Quercetin insulin Homo sapiens
2 Quercetin effectively restored high fructose-induced hypothalamic insulin signaling defect by up-regulating the phosphorylation of insulin receptor and protein kinase B. Quercetin insulin Homo sapiens
3 Thus, quercetin with the central activity may be a therapeutic for high fructose-induced insulin resistance and hyperlipidemia in humans. Quercetin insulin Homo sapiens