Title : p53 inactivation decreases dependence on estrogen/ERK signalling for proliferation but promotes EMT and susceptility to 3-bromopyruvate in ERĪ±+ breast cancer MCF-7 cells.

Pub. Date : 2014 Mar 15

PMID : 24486524






1 Functional Relationships(s)
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1 CONCLUSIONS: (a) ERalpha(+) breast cancer cells dysfunctional for TP53 which proliferate irrespective of low estrogen and chemical MEK inhibition are likely to increase metabolic consumption becoming increasingly susceptible to 3-BrPA; (b) targeting the pyruvate pathway may improve response to endocrine therapy in ERalpha(+) breast cancer with p53 dysfunction. Pyruvic Acid tumor protein p53 Homo sapiens