Title : Structural requirements for the activity of antifolates as substrates for mammalian folylpolyglutamate synthetase.

Pub. Date : 1987

PMID : 2448651






1 Functional Relationships(s)
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1 There was some correlation between FPGS substrate activity and the potency of folate antimetabolites as cytotoxic compounds but not necessarily as compounds selectively cytotoxic to tumor cells. Folic Acid folylpolyglutamate synthase Homo sapiens