Title : Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity.

Pub. Date : 2014 Apr 5

PMID : 24485892






2 Functional Relationships(s)
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1 (2R, 3R)-Obtusafuran (1) also reduced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production, and these anti-neuroinflammatory effects were shown to be correlated with the suppression of the phosphorylation and degradation of inhibitor of nuclear factor kappa B-alpha (IkappaB-alpha), and nuclear factor kappa B nuclear (NF-kappaB) translocation and DNA binding activity. obtusafuran interleukin 1 beta Mus musculus
2 (2R, 3R)-Obtusafuran (1) also reduced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production, and these anti-neuroinflammatory effects were shown to be correlated with the suppression of the phosphorylation and degradation of inhibitor of nuclear factor kappa B-alpha (IkappaB-alpha), and nuclear factor kappa B nuclear (NF-kappaB) translocation and DNA binding activity. obtusafuran interleukin 1 beta Mus musculus