Pub. Date : 2014 Mar 15
PMID : 24485890
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro, saxagliptin inhibited FBS-, insulin- and IGF1-induced ERK phosphorylation and cell proliferation, in both MSC and MC3T3E1 preosteoblasts. | saxagliptin | insulin-like growth factor 1 | Rattus norvegicus |
| 2 | In conclusion, orally administered saxagliptin induced alterations in long-bone microarchitecture that could be related to its in vitro down-regulation of the ERK signaling pathway for insulin and IGF1 in MSC, thus decreasing the osteogenic potential of these cells. | saxagliptin | insulin-like growth factor 1 | Rattus norvegicus |