Pub. Date : 2014
PMID : 24484986
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Receptor antagonists that selectivity target central nAChR subtypes mediating nicotine-evoked DA release should have efficacy as tobacco use cessation agents with the therapeutic advantage of a limited side-effect profile. | Nicotine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |
| 2 | More recent data have shown that novel, nonquaternary bis-1,2,5,6-tetrahydropyridine analogs potently inhibit (IC50<1nM) nicotine-evoked DA release in vitro by acting as antagonists at alpha-CtxMII-sensitive nAChR subtypes; these compounds also decrease NIC self-administration in rats. | Nicotine | cholinergic receptor nicotinic beta 1 subunit | Rattus norvegicus |