Pub. Date : 2013 Nov
PMID : 24484556
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To examine the effects of niacin on lysophosphatidylcholine (LPC)-induced intercellular adhesion molecule-1 (ICAM-1), and gained insight to the mechanisms. | Niacin | intercellular adhesion molecule 1 | Homo sapiens |
| 2 | OBJECTIVE: To examine the effects of niacin on lysophosphatidylcholine (LPC)-induced intercellular adhesion molecule-1 (ICAM-1), and gained insight to the mechanisms. | Niacin | intercellular adhesion molecule 1 | Homo sapiens |
| 3 | Compared with the LPC 8 h, niacin reduced LPC-induced ICAM-1 mRNA expression (3.85 +- 0.14), and showed a dose-dependent manner (F = 8.06, P < 0.01), while SB203580 could not effectively reduce the ICAM-1 mRNA (8.09 +- 0.11). | Niacin | intercellular adhesion molecule 1 | Homo sapiens |
| 4 | Compared with the LPC 8 h, niacin reduced LPC-induced ICAM-1 mRNA expression (3.85 +- 0.14), and showed a dose-dependent manner (F = 8.06, P < 0.01), while SB203580 could not effectively reduce the ICAM-1 mRNA (8.09 +- 0.11). | Niacin | intercellular adhesion molecule 1 | Homo sapiens |
| 5 | CONCLUSION: Niacin prevented LPC-induced endothelial dysfunction by reducing expression of ICAM-1. | Niacin | intercellular adhesion molecule 1 | Homo sapiens |