Title : Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation.

Pub. Date : 2014

PMID : 24484539






2 Functional Relationships(s)
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1 Among the substrates that are preferably metabolized by CYP3A4, including carebastine, itraconazole, haloperidol, and fluvastatin, the former three compounds were found to closely dock to the heme region of CYP3A4 but not to that of CYP3A5. Itraconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Among the substrates that are preferably metabolized by CYP3A4, including carebastine, itraconazole, haloperidol, and fluvastatin, the former three compounds were found to closely dock to the heme region of CYP3A4 but not to that of CYP3A5. Itraconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens