Title : Involvement of extracellular signal-regulated kinase (ERK1/2)-p53-p21 axis in mediating neural stem/progenitor cell cycle arrest in co-morbid HIV-drug abuse exposure.

Pub. Date : 2014 Jun

PMID : 24469921






2 Functional Relationships(s)
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1 Furthermore HIV-Tat and morphine exposure increased activation of extracellular signal-regulated kinase-1/2 (ERK1/2), enhanced levels of p53 and p21, and decreased cyclin D1 and Akt levels in NPCs. Morphine mitogen-activated protein kinase 3 Homo sapiens
2 Regulated by ERK1/2 and p53, p21 was found to be indispensible for Tat and morphine mediated cell cycle arrest. Morphine mitogen-activated protein kinase 3 Homo sapiens