Pub. Date : 2014 Mar
PMID : 24467666
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a beta-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase. | beta-Alanine | aminoadipate-semialdehyde dehydrogenase | Homo sapiens |
| 2 | Vertebrate Acyl CoA synthetase family member 4 (ACSF4-U26) is a beta-alanine-activating enzyme homologous to bacterial non-ribosomal peptide synthetase. | beta-Alanine | aminoadipate-semialdehyde dehydrogenase | Homo sapiens |
| 3 | Remarkably, the adenylation domain of plant ACSF4-U26 show greater identity with Ebony, the insect enzyme that ligates beta-alanine to several amines, than with vertebrate or insect ACSF4-U26, and prediction of its specificity suggests that it activates beta-alanine. | beta-Alanine | aminoadipate-semialdehyde dehydrogenase | Homo sapiens |
| 4 | Remarkably, the adenylation domain of plant ACSF4-U26 show greater identity with Ebony, the insect enzyme that ligates beta-alanine to several amines, than with vertebrate or insect ACSF4-U26, and prediction of its specificity suggests that it activates beta-alanine. | beta-Alanine | aminoadipate-semialdehyde dehydrogenase | Homo sapiens |
| 5 | This effect was mimicked by cysteamine and dithiothreitol, and was unaffected by absence of the PQQDH-related domain, suggesting that beta-alanine transfer onto thiols is catalysed by the ACSF4-U26 adenylation domain, but is physiologically irrelevant. | beta-Alanine | aminoadipate-semialdehyde dehydrogenase | Homo sapiens |
| 6 | We conclude that ACSF4-U26 is a beta-alanine-activating enzyme, and hypothesize that it is involved in a rare intracellular reaction, possibly an infrequent post-translational or post-transcriptional modification. | beta-Alanine | aminoadipate-semialdehyde dehydrogenase | Homo sapiens |