Title : OSU-CG5, a novel energy restriction mimetic agent, targets human colorectal cancer cells in vitro.

Pub. Date : 2014 Mar

PMID : 24464048






1 Functional Relationships(s)
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1 Furthermore, both OSU-CG5 and resveratrol induced dose-dependent energy restriction in the cells: they suppressed glucose uptake and Akt phosphorylation, decreased the levels of p-mTOR and p-p70S6K, increased the levels of ER stress response proteins GRP78 and GADD153, and increased the level of beta-TrCP, which led to the downregulation of cyclin D1 and Sp1. OSU-CG5 heat shock protein family A (Hsp70) member 5 Homo sapiens