Title : Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies.

Pub. Date : 2014 Apr

PMID : 24459244






2 Functional Relationships(s)
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1 Molecular modeling identified key amino acids involved in the binding of UDP-GlcUA and UDP-Glc to UGT2B7. Uridine Diphosphate Glucuronic Acid UDP glucuronosyltransferase family 2 member B7 Homo sapiens
2 Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-GlcUA to UGT2B7 is higher than that of UDP-Glc. Uridine Diphosphate Glucuronic Acid UDP glucuronosyltransferase family 2 member B7 Homo sapiens