Title : Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study.

Pub. Date : 2014 Apr 3

PMID : 24458439






1 Functional Relationships(s)
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1 Ruxolitinib improved survival independent of mutation profile and reduced the risk of death in patients harboring a set of prognostically detrimental mutations (ASXL1, EZH2, SRSF2, IDH1/2) with an hazard ratio of 0.57 (95% confidence interval: 0.30-1.08) vs best available therapy. ruxolitinib ASXL transcriptional regulator 1 Homo sapiens