Title : Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids.

Pub. Date : 2014 Feb 15

PMID : 24457093






1 Functional Relationships(s)
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1 In contrast, the novel heterocyclic AdArs containing a thiazole or pyrazine ring linked to a benzoic acid motif were potent inhibitors of both IKKalpha and IKKbeta, which in most cases paralleled significant growth inhibitory and apoptosis inducing activities. Pyrazines component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens