Pub. Date : 2014 Jun
PMID : 24456325
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of insulin against hydrogen peroxide-induced oxidative damages in differentiated SH-SY5Y cells. | Hydrogen Peroxide | insulin | Homo sapiens |
| 2 | In the present study, we have investigated the neuroprotective effects of insulin on H2O2-induced toxicity of retinoic acid (RA)-differentiated SH-SY5Y cells. | Hydrogen Peroxide | insulin | Homo sapiens |
| 3 | Further assays showed that 24 h of 100 microM H2O2-induced significant changes in the levels of lactate dehydrogenase (LDH), nitric oxide (NO), ROS, and calcium ion (Ca2+) in neuronal cells, but insulin can effectively diminish the H2O2-induced oxidative damages to these cells. | Hydrogen Peroxide | insulin | Homo sapiens |
| 4 | Moreover, cells treated with insulin increased H2O2-induced suppression of glutathione levels and exerted an apparent suppressive effect on oxidative products. | Hydrogen Peroxide | insulin | Homo sapiens |
| 5 | The treatment of insulin had played a protective effect on H2O2-induced oxidative stress related to the Akt/Bcl-2 pathways. | Hydrogen Peroxide | insulin | Homo sapiens |