Title : Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.

Pub. Date : 2014

PMID : 24454930






2 Functional Relationships(s)
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1 The data indicated that the stimulation of J774 cells with LPS and ATP induces the features of pyroptosis, including the expression of IL-1beta mRNA and protein, activation of caspase-1, inflammasome formation and cell death. Adenosine Triphosphate interleukin 1 beta Mus musculus
2 Moreover, LL-37 inhibits the LPS/ATP-induced IL-1beta expression, caspase-1 activation, inflammasome formation, as well as cell death. Adenosine Triphosphate interleukin 1 beta Mus musculus