Pub. Date : 2014 May
PMID : 24453031
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The CYP1B1 Leu432Val polymorphism and risk of urinary system cancers. | leu432val | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | The CYP1B1 Leu432Val polymorphism leads to leucine to valine substitution at codon 432. | leu432val | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 3 | A lot of studies have shown that the CYP1B1 Leu432Val polymorphism was associated with urinary system cancers, especially prostate cancer. | leu432val | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 4 | In this meta-analysis, by searching online databases and references of related reviews, we identified 17 eligible studies to assess the relationship between CYP1B1 Leu432Val polymorphism and urinary system cancers, including 7,783 cancer cases and 7,238 controls. | leu432val | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 5 | By pooling all eligible studies, we found that the CYP1B1 Leu432Val polymorphism was not associated with overall urinary system cancers. | leu432val | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 6 | In conclusion, based on 17 eligible studies, we found that the CYP1B1 Leu432Val polymorphism was associated with an increased risk of prostate cancer, while no association of bladder cancer was observed. | leu432val | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |