Title : A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.

Pub. Date : 2014 Mar 14

PMID : 24451382






2 Functional Relationships(s)
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1 We show in SirT1-overexpressing HepG2 cells that oxidants (nitrosocysteine and hydrogen peroxide) or metabolic stress (high palmitate and high glucose) inactivated SirT1 by reversible oxidative post-translational modifications (OPTMs) on three cysteines. Hydrogen Peroxide sirtuin 1 Homo sapiens
2 We show in SirT1-overexpressing HepG2 cells that oxidants (nitrosocysteine and hydrogen peroxide) or metabolic stress (high palmitate and high glucose) inactivated SirT1 by reversible oxidative post-translational modifications (OPTMs) on three cysteines. Hydrogen Peroxide sirtuin 1 Homo sapiens