Pub. Date : 2014 Apr
PMID : 24448832
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. | Nickel | ATP binding cassette subfamily B member 1 | Canis lupus familiaris |
| 2 | Here, we investigated the role of ABCB1 in nickel-induced stress signaling mediated by reactive oxygen species (ROS) and ceramides. | Nickel | ATP binding cassette subfamily B member 1 | Canis lupus familiaris |
| 3 | ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel. | Nickel | ATP binding cassette subfamily B member 1 | Canis lupus familiaris |
| 4 | ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel. | Nickel | ATP binding cassette subfamily B member 1 | Canis lupus familiaris |
| 5 | ABCB1 protects against nickel toxicity as PSC833, an ABCB1 blocker, augmented the decrease in cell viability by nickel. | Nickel | ATP binding cassette subfamily B member 1 | Canis lupus familiaris |
| 6 | Moreover, nickel toxicity was attenuated in renal MDCK cells stably overexpressing ABCB1. | Nickel | ATP binding cassette subfamily B member 1 | Canis lupus familiaris |
| 7 | In conclusion, nickel induces a ROS-ceramide pathway to cause apoptotic cell death as well as activate adaptive survival responses, including upregulation of ABCB1, which improves cell survival by extruding proapoptotic (glucosyl)ceramides. | Nickel | ATP binding cassette subfamily B member 1 | Canis lupus familiaris |