Pub. Date : 2014 May
PMID : 24447140
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of interleukin-1beta production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia. | Cyclic AMP | interleukin 1 beta | Mus musculus |
| 2 | Forskolin and a cAMP derivative, which specifically stimulates protein kinase A (PKA), mimicked the proton actions, and PKA inhibitors reversed the acidic pH-induced IL-1beta mRNA expression. | Cyclic AMP | interleukin 1 beta | Mus musculus |
| 3 | We conclude that extracellular acidic pH inhibits lipopolysaccharide-induced IL-1beta production, at least partly, through the TDAG8/cAMP/PKA pathway, by inhibiting extracellular signal-related kinase and c-Jun N-terminal kinase activities, in mouse microglia. | Cyclic AMP | interleukin 1 beta | Mus musculus |