Title : Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.

Pub. Date : 2014 Feb 10

PMID : 24446489






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Idiopathic pulmonary arterial hypertension (PAH [IPAH]) is an insidious and potentially fatal disease linked to a mutation or reduced expression of bone morphogenetic protein receptor 2 (BMPR2). p-Aminohippuric Acid bone morphogenetic protein receptor type 2 Homo sapiens
2 Idiopathic pulmonary arterial hypertension (PAH [IPAH]) is an insidious and potentially fatal disease linked to a mutation or reduced expression of bone morphogenetic protein receptor 2 (BMPR2). p-Aminohippuric Acid bone morphogenetic protein receptor type 2 Homo sapiens
3 Thus, reduced BMPR2 can subvert a stress granule response, heighten GM-CSF mRNA translation, increase inflammatory cell recruitment, and exacerbate PAH. p-Aminohippuric Acid bone morphogenetic protein receptor type 2 Homo sapiens