Pub. Date : 1987 Aug
PMID : 2443931
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AFP has been shown to induce mobilization of arachidonic acid and consequently an enhanced production of leukotrienes. | Leukotrienes | alpha fetoprotein | Mus musculus |
| 2 | Indomethacin used in combination with AFP partly loses its inhibiting effect on PGE2 synthesis and paradoxically leads to a "superactivation" of P388D1 cells demonstrated by a very high arachidonic acid mobilization, an enhancement of both leukotriene synthesis and cyclooxygenase activity. | Leukotrienes | alpha fetoprotein | Mus musculus |
| 3 | In addition, it is shown that the effects of AFP and AFP+Indomethacin on cyclooxygenase activity might be explained by the endogenous synthesis of leukotrienes. | Leukotrienes | alpha fetoprotein | Mus musculus |
| 4 | In addition, it is shown that the effects of AFP and AFP+Indomethacin on cyclooxygenase activity might be explained by the endogenous synthesis of leukotrienes. | Leukotrienes | alpha fetoprotein | Mus musculus |