Pub. Date : 2014 Jan 20
PMID : 24438088
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Recent studies have shown that glucosamine inhibits the proliferation of various human cancer cell lines and downregulates the activity of COX-2, HIF-1alpha, p70S6K, and transglutaminase 2. | Glucosamine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Because the IGF-1R/Akt pathway is a common upstream regulator of p70S6K, HIF-1alpha, and COX-2, we hypothesized that glucosamine inhibits cancer cell proliferation through this pathway. | Glucosamine | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |