Title : Isothiocyanate-cysteine conjugates protect renal tissue against cisplatin-induced apoptosis via induction of heme oxygenase-1.

Pub. Date : 2014 Mar

PMID : 24434421






1 Functional Relationships(s)
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1 Inhibitors of the pro-survival pathways ERK, MAPK and PI3K almost completely abolished the increase in HO-1 induction and heme oxygenase activity, while the JNK pathway appeared to be mainly involved in the apoptosis triggered by the isothiocyanates. Isothiocyanates mitogen-activated protein kinase 8 Rattus norvegicus