Title : Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.

Pub. Date : 2015 May

PMID : 24431397






2 Functional Relationships(s)
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1 Inhibition of CK2 by TBB abrogated the TGFbeta-induced activation of JAK2/STAT3 signalling and prevented the stimulatory effects of TGFbeta on collagen release and myofibroblasts differentiation in cultured fibroblasts. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate signal transducer and activator of transcription 3 Homo sapiens
2 The antifibrotic effects of TBB were accompanied by reduced activation of JAK2/STAT3 signalling in vivo. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate signal transducer and activator of transcription 3 Homo sapiens