Title : Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis.

Pub. Date : 2015 May

PMID : 24431397






3 Functional Relationships(s)
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1 CK2 signalling was inhibited by the selective CK2 inhibitor 4, 5, 6, 7-Tetrabromobenzotriazole (TBB). 2-ethylhexyl 2,3,4,5-tetrabromobenzoate casein kinase 2, alpha prime polypeptide Mus musculus
2 CK2 signalling was inhibited by the selective CK2 inhibitor 4, 5, 6, 7-Tetrabromobenzotriazole (TBB). 2-ethylhexyl 2,3,4,5-tetrabromobenzoate casein kinase 2, alpha prime polypeptide Mus musculus
3 Inhibition of CK2 by TBB abrogated the TGFbeta-induced activation of JAK2/STAT3 signalling and prevented the stimulatory effects of TGFbeta on collagen release and myofibroblasts differentiation in cultured fibroblasts. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate casein kinase 2, alpha prime polypeptide Mus musculus