Title : IL-1 blockade in autoinflammatory syndromes.

Pub. Date : 2014

PMID : 24422572






1 Functional Relationships(s)
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1 The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1beta-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. Glucose NLR family pyrin domain containing 3 Homo sapiens