Title : Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.

Pub. Date : 2014 Mar 21

PMID : 24415766






1 Functional Relationships(s)
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1 Two classes of IL-6 SOMAmers were isolated from modified DNA libraries containing 40 random positions and either 5-(N-benzylcarboxamide)-2"-deoxyuridine (Bn-dU) or 5-[N-(1-naphthylmethyl)carboxamide]-2"-deoxyuridine (Nap-dU) replacing dT. Thymidine interleukin 6 Homo sapiens