Title : Synergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines.

Pub. Date : 2014 Jan 10

PMID : 24413065






1 Functional Relationships(s)
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1 In all three cell lines [Gem+Clo+Ed] decreased the level of phosphorylation of the pro-survival protein AKT and activated the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) stress signaling pathway, which in J45.01 cells resulted in the phosphorylation and heterodimerization of the transcription factors ATF2 and c-Jun. edelfosine AKT serine/threonine kinase 1 Homo sapiens