Title : Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells.

Pub. Date : 2014

PMID : 24407515






1 Functional Relationships(s)
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1 However, resistance to doxorubicin and tamoxifen were alleviated in MCF-7/GSK-3beta(KD) cells upon co-treatment with an MEK inhibitor, indicating regulation of this resistance by the Raf/MEK/ERK pathway. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens