Title : Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.

Pub. Date : 2013 Dec

PMID : 24403854






1 Functional Relationships(s)
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1 Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from nicotinamide (NAM) through the nicotinamide phosphoribosyltransferase (NAMPT)-dependent salvage pathway. Niacinamide nicotinamide phosphoribosyltransferase Homo sapiens