Title : IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis.

Pub. Date : 2013 Dec

PMID : 24403255






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Because heretofore the role of IL-4 in DMBA/TPA (9,10-dimethyl-1,2-benz-anthracene/12-O-tetradecanoylphorbol-13-acetate) two-stage carcinogenesis was not studied, we performed such experiments using either IL-4(-/-) or IL-4Ralpha(-/-) mice. Tetradecanoylphorbol Acetate interleukin 4 Mus musculus
2 Taken together, our results indicate that the course of DMBA/TPA- and MCA-induced carcinogenesis is affected differently by IL-4 versus IL-13-mediated inflammatory cascades. Tetradecanoylphorbol Acetate interleukin 4 Mus musculus