Title : SMAD4 mutations causing Myhre syndrome result in disorganization of extracellular matrix improved by losartan.

Pub. Date : 2014 Aug

PMID : 24398790






1 Functional Relationships(s)
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1 Increased TGF-beta signaling and progression of aortic root dilation in Marfan syndrome can be prevented by the antihypertensive drug losartan, a TGF-beta antagonists and angiotensin-II type 1 receptor blocker. Losartan transforming growth factor beta 1 Homo sapiens