Title : Casein kinase 2 inhibition attenuates cholesterol oxidation product-induced apoptosis by suppressing the activation of the mitochondrial pathway and the caspase-8- and bid-dependent pathways.

Pub. Date : 2014 Jan

PMID : 24398405






1 Functional Relationships(s)
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1 Treatment with TBB inhibited the 7-ketocholesterol-induced decrease in Bid, Bcl-2 and survivin protein levels, increase in Bax levels, loss of the mitochondrial transmembrane potential, cytochrome c release, activation of caspases (-8, -9 and -3), cleavage of PARP-1, and increase in the tumor suppressor p53 levels. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate poly (ADP-ribose) polymerase 1 Rattus norvegicus