Title : Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation.

Pub. Date : 2014 Nov

PMID : 24397597






2 Functional Relationships(s)
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1 We found that quercetin inhibited the proliferation of MM cells in a dose- and time-dependent manner, accompanied by reduced IQGAP1 expression at mRNA and protein levels, and reduced extracellular signal-regulated kinase 1/2 (ERK1/2) activation. Quercetin mitogen-activated protein kinase 3 Homo sapiens
2 Furthermore, we found that quercetin inhibited the interaction between IQGAP1 and ERK1/2 in RPMI8226 cells. Quercetin mitogen-activated protein kinase 3 Homo sapiens