Pub. Date : 2013
PMID : 24396568
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-alpha: the role of PKC-beta2 and NADPH oxidase. | Nitroglycerin | tumor necrosis factor | Homo sapiens |
| 2 | We determined whether chronic administration with nitroglycerine compromises the protective effects of propofol against tumor necrosis factor (TNF-) induced toxicity in endothelial cells by PKC- beta2 dependent NADPH oxidase activation. | Nitroglycerin | tumor necrosis factor | Homo sapiens |
| 3 | We determined whether chronic administration with nitroglycerine compromises the protective effects of propofol against tumor necrosis factor (TNF-) induced toxicity in endothelial cells by PKC- beta2 dependent NADPH oxidase activation. | Nitroglycerin | tumor necrosis factor | Homo sapiens |
| 4 | TNF-alpha increased the levels of superoxide, Nox (nitrate and nitrite), malondialdehyde, and nitrotyrosine production, accompanied by increased protein expression of p-PKC-beta2, gP91phox, and endothelial cell apoptosis, whereas all these changes were further enhanced by nitroglycerine. | Nitroglycerin | tumor necrosis factor | Homo sapiens |
| 5 | It is concluded that nitroglycerine comprises the protective effects of propofol against TNF-alpha stimulation in endothelial cells, primarily through PKC-beta2 dependent NADPH oxidase activation. | Nitroglycerin | tumor necrosis factor | Homo sapiens |