Pub. Date : 2014 Jan 24
PMID : 24388981
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax. | polyglutamine | caspase 7 | Mus musculus |
| 2 | This study reveals that polyglutamine oligomers augmented at ER induce insertion of Bax into the ER membrane, thereby activating caspase-7. | polyglutamine | caspase 7 | Mus musculus |
| 3 | We can conclude that polyglutamine expansion may drive caspase-7 activation by disrupting the ER membrane. | polyglutamine | caspase 7 | Mus musculus |